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  • Tailoring of medical treatment: Hemostasis and thrombosis towards precision medicine.  G. Di Minno, E. Tremoli. Haematologica, 2017;102:411-418.


  • The investigation and management of neonatal haemostasis and thrombosis. Williams MD, Chalmers EA, Gibson BE; Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology. Br J Haematol. 2002; 119(2):295-309.

Abstract: These guidelines address developmental aspects of neonatal haemostasis and thrombosis, the laboratory investigation of the neonate, and the diagnosis and clinical management of haemostatic and thrombotic conditions occurring in this period (defined as the first 4 weeks of life following birth). Relevant scientific papers were identified by a systematic literature review from Medline 1975-2000 using index terms which incorporated the various component subjects of these guidelines. Further publications were obtained from the references cited and from reviews known to the members of the working party and to the Haemostasis and Thrombosis Task Force. Evidence and graded recommendations presented in these guidelines are in accordance with the US Agency for Health Care Policy and Research, as described in the Appendix. It will be noted that there is a lack of a strong evidence base for many of the recommendations suggested, as the appropriate clinical and laboratory trials have not been and perhaps never will be undertaken in neonates. Most of the recommendations are therefore of Grade C evidence levels IV: higher levels are mentioned specifically throughout the document when relevant.


  • Guidelines on the investigation and management of the antiphospholipid syndrome. Greaves M, Cohen H, MacHin SJ, Mackie I. Br J Haematol. 2000; 109(4):704-15.
  • The rare coagulation disorders - review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation. Bolton-Maggs PH, Perry DJ, Chalmers EA, Parapia LA, Wilde JT, Williams MD, Collins PW, Kitchen S, Dolan G, Mumford AD. Haemophilia. 2004; 10(5):593-628.

Abstract: The rare coagulation disorders are heritable abnormalities of haemostasis that may present significant difficulties in diagnosis and management. This review summarizes the current literature for disorders of fibrinogen, and deficiencies of prothrombin, factor V, FV + VIII, FVII, FX, the combined vitamin K-dependent factors, FXI and FXIII. Based on both collective clinical experience and the literature, guidelines for management of bleeding complications are suggested with specific advice for surgery, spontaneous bleeding, management of pregnancy and the neonate. We have chosen to include a section on Ehlers-Danlos Syndrome because haematologists may be consulted about bleeding manifestations in such patients.


  • CLSI (formerly NCCLS): Platelet function testing by aggregometry; Proposed Guideline. CLSI document H58-A (ISBN 1-56238-643-3). Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2008.

Abstract: Platelet Function Testing by Aggregometry; Proposed Guideline provides concrete, standard procedures for using aggregometry to assess platelet function in patient specimens and samples, with the intent to achieve greater uniformity of results by laboratories following these guidelines. Descriptions of light transmission aggregometry, whole blood impedence aggregometry, and shear-flow technologies are provided so both long-time and new users may stablish consistent, reproducible platelet function testing programs in their laboratories.


Last modification on 18 May 2017


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Click on the following link to access to the CLSI guidelines website:


Click on the following link to access to the BCSH guidelines website:

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